The adoption of metal additive manufacturing into the production of passive microwave components is still in its relative infancy.However, it is of increasing interest due to the offer of geometrical design freedom Fine Jewlery ($50-150) and significant weight reduction.The electrical properties of additive manufactured components are still inferio
Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective
Discogenic back pain is one of the most diffused musculoskeletal pathologies and a hurdle to a good quality of life for millions of people.Existing therapeutic options are exclusively directed at reducing symptoms, not at targeting the underlying, still poorly understood, degenerative processes.Common intervertebral disc (IVD) disease models still
Structural distinctions in BMPs underlie divergent signaling in spinal neurons
Abstract Background In dorsal spinal neurons and monocytes, bone morphogenetic protein (BMP)7 activates distinct Hoodies/Fleece transduction pathways, one leading to inductive specification and the other to axon orientation and chemotaxis.BMP7-evoked induction, also stimulated by the closely related BMP6, acts through a Smad cascade, leading to nuc
Research progress of ALK kinase domain drug resistance mutation and its future countermeasures
Anaplastic lymphoma kinase (ALK) is one of the common oncogenic driver genes in non-small cell lung cancer (NSCLC).Tyrosine kinase inhibitors (TKIs) have achieved excellent therapeutic effects in patients with ALK fusion positive NSCLC.However, patients will eventually develop resistance to TKIs.Acquired molecular drug resistance mechanisms, such a